DEVELOPMENT OF POLYMERIC DOSAGE FORMS OF THE ANTIBACTERIAL COMPOUND ETHONIUM

Zebo Urinova

Doctoral student at Samarkand State University

Tuygun Babaev

Professor of the National University of Uzbekistan, Doctor of Chemical Sciences

Makhmud Karimov

Associate Professor of the National University of Uzbekistan, Doctor of Chemical Sciences

Sevinch Mavlonova

Chirchik branch Tashkent Medical Academy

Keywords: pektine, etonij, polyelectrolytes, polymer complex, antisflam-matory mean, hidrodinamical property, IK-spectroskopy, рotentiometric titration, viscosimetry.


Abstract

The complex formation of the medicinal compound aethonium with the natural polymer apple pectin was studied using the methods of IR spectroscopy, potentiometric titration and viscometry. The ways of modifying a carboxyl-containing polymer, highly soluble in water, with an organic physiologically active compound, aethonium, used in veterinary practice as an anti-inflammatory agent to obtain its prolonged dosage forms have been studied.


References

Yun Y.H., Lee B.K., Park I.K. Controlled Drug Delivery: Historical perspective for the next generation//Journal of Controlled Release. 2015.- V. 219.- P. 2-7.

Rashidova S.Sh. Prospects for the development of polymer science and technology in the Republic of Uzbekistan on the threshold of the 21st century. In the collection “Proceedings of the IKhPP”. Tashkent. 1999. -S. 42-47.

Hoffman A.S. The origins and evolution of “controlled” drug delivery systems //Journal of Controlled Release.- 2008.- V.132.- P.153 – 163.

Panarin E.F. Polymers in medicine and pharmacy. St. Petersburg: Publishing house. Polytechnic University, 2008. -S. 8-191.

Khutoryanskiy V.V. Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications//Int. J. Pharm. 2007. Vol. 334.-P.15-26.

Obeidat, W.M., Abu Znait A.H., Sallam A.A. Novel combination of anionic and cationic polymethacrylate polymers for sustained release tablet preparation//Drug Dev. Ind. Pharm.2008.Vol.34. -P. 650-660.

Zezin A.B. Polyelectrolyte complexes: past, present, future. VI-All-Russian Kargin Conference “Polymers-2014”. Abstract. report 2014. M., Moscow State University, T.1. -WITH. 74-75.

Brugemanno R., Haupt R., Lei Ye., Yilmaz E., Mosbach K. New configurations and applications of molecularly imprinted pjlymtrs//J. Chromatografi. 2000.Vol. 889. No. 4. –P. 15-24.

Shurshina A.S., Timerbaeva G.R., Lazdin R.Yu. Study of the interaction of pectin with some antibiotics // Bulletin of the Bashkir University. 2020. No. 4. -WITH. 76-77.

Khairulina R.R., Timerbaeva G.R., Shurshina A.S. Study of the interaction of pectin with cefazolin using IR spectroscopy // Bulletin of the Bashkir University. 2017. No. 2. -WITH. 55-56.

Degtyarev L.S., Kupchik M.P., Donchenko L.V. and others. Properties and structure of galacturonic acid in pectin production technology // Izv. Universities. Food technology. 2002. No. 4. P. 15-18.

Kukin, M. Yu. Improvement of technology for obtaining pectin from apples // Scientific journal of NRU ITMO. Series “Processes and apparatus of food production”. 2017. – No. 2 (32). – P. 9–17.

Kamaeva S.S., Potselueva L.A., Sabirova F.M. Spermicidal activity of aethonium. RF patent. RU 2229878. 2004.

Volkova N.L., Lebedeva N.Sh., Parfenyuk E.V. Complexation of D-xylose and L-arabinose with 18-crown-6 in aqueous solutions using calorimetry, densimetry and viscometry methods // Coordination. chemistry. 2005. T. 31. No. 12. P. 946-950.

Khazanova E.S., Egorov D.V., Nogai S.Yu. Oral delivery system for protein substances (options), protective shell of the delivery system (options). RF patent. RU 2665367. 2018.

16. Filippov M.P. Infrared spectra of pectin substances. Chisinau: Shtiintsa, 1978. 138 P.

17. Mironov V.A., Yankovsky S.A. Spectroscopy in organic chemistry. -M.: Chemistry, 1995. p. 42-48.